Joker His real name is Commander Diasuke Kujirai. Brought his plans for a cyborg squad to fruitition and became its leader. He is a brilliant bionics specialist and engineer. It was he who initiated the JAKQ project and recruited the various team members. He was a married man and a young daughter. He was later to become the head of the ISSIS' advanced engineering branch in Episode 23 and was replaced by Big One. He returned in Episode 35.

ISSIS Agents 7 (Hayashi Keiko), 8 (Yamamoto Junko), 9 (Iijima Yoshiko), and Agent 10 were female assistants of JAKQ who assisted the JAKQ at various times. Commander Robert is the ISSIS New York headquarters head. Approved of Kujirai's cyborg project. The ISSIS Hamster was Kujirai's pet cyborg that talks. It stayed behind even when Kujirai went to New York. Hime Tamasaburou ISSIS member who poses as a cook in traditional bathing wear on a bicycle. He is from Matsuyama in Shikoku and specializes in instant kind ramen. He appears from Episodes 23-35.